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Talele NP, Kumra H, Gomes-Santos IL, Ho WW, Andersson P, Siwicki M, Huang P, Duda DG, Pittet MJ, Fukumura D, Jain RK
IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity.
J Immunother Cancer. 2025;13(5):ePub - PMID: 40413022 - PMCID: PMC12104899 - DOI: 10.1136/jitc-2024-011404
Lei PJ, Padera TP
Closing in on pacemaker cells.
Elife. 2025;14:ePub - PMID: 40693539 - PMCID: PMC12283070 - DOI: 10.7554/eLife.108102
Munn LL, Jain RK
Challenges and opportunities for the next generation of computational tumor models.
PLoS Biol. 2025;23(7):e3003269 - PMID: 40700394 - PMCID: PMC12286354 - DOI: 10.1371/journal.pbio.3003269
Mahfoud S, Padera TP
S1PR1, an endothelial-immune influencer.
J Exp Med. 2025;222(9):ePub - PMID: 40663043 - DOI: 10.1084/jem.20251056
Hale AT, Kalailingam P, Kundishora AJ, Reeves BC, Brastianos PK, Shih HA, Jain RK, Ning M, Stapleton CJ, Patel AB, Smith ER, Chapman PH, Rabinov JD, Kleinstiver BP, Musolino PL, Kahle KT
An opportune time for targeted brain arteriovenous malformation therapy.
J Neurosurg. 2025;:1-4 - PMID: 40644723 - DOI: 10.3171/2025.4.JNS25260
Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP
A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics.
Npj Imaging. 2025;3(1):2 - PMID: 40604254 - PMCID: PMC12091688 - DOI: 10.1038/s44303-024-00061-z
Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LH, Singh A, Fu J, Waterton SK, Cheng YC, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Immunity. 2025;58(7):1688-1705.e9 - PMID: 40592342 - PMCID: PMC12233199 - DOI: 10.1016/j.immuni.2025.06.005
Voutouri C, Munn LL, Stylianopoulos T, Jain RK
Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions.
PLoS Comput Biol. 2025;21(6):e1013163 - PMID: 40504865 - PMCID: PMC12201673 - DOI: 10.1371/journal.pcbi.1013163
Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK
Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
Clin Cancer Res. 2025;:ePub - PMID: 40495423 - DOI: 10.1158/1078-0432.CCR-24-4159
Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK
Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Cancer Res. 2025;:ePub - PMID: 40439571 - DOI: 10.1158/0008-5472.CAN-24-2232
Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR, Neurofibromatosis Clinical Trials Consortium
Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
J Neurooncol. 2025;173(3):751-757 - PMID: 40434540 - DOI: 10.1007/s11060-025-05020-1
Munn LL
The cellular dance that splits vessels.
Proc Natl Acad Sci U S A. 2025;122(22):e2508260122 - PMID: 40424133 - PMCID: PMC12146740 - DOI: 10.1073/pnas.2508260122
Nia HT, Munn LL, Jain RK
Probing the physical hallmarks of cancer.
Nat Methods. 2025;:ePub - PMID: 39815103 - DOI: 10.1038/s41592-024-02564-4
Duda D, Liu X, Liu Z, Kobayashi T, Lei PJ, Shi Y, Yuan D, Wang J, Li M, Matsui A, Mafra K, Huang P, Kuang M, Bod L
Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma.
Res Sq. 2025;:ePub - PMID: 40321752 - PMCID: PMC12047993 - DOI: 10.21203/rs.3.rs-6355345/v1
Gkika E, Firat E, Adebahr S, Graf E, Popp I, Eichhorst A, Radicioni G, Lo SS, Spohn SKB, Nestle U, Nicolay NH, Niedermann G, Grosu AL, Duda DG
A prospective study of immune responses in patients with lung metastases treated with stereotactic body radiotherapy with or without concurrent systemic treatment.
Radiother Oncol. 2025;207:110889 - PMID: 40209858 - DOI: 10.1016/j.radonc.2025.110889
Saeed A, Colby S, Oberstein PE, Duda DG, Park R, Agarwal R, Figueroa-Moseley C, Vaidya R, Unger JM, Guthrie KA, Rocha FG, Senthil M, Safyan RA, Wainberg ZA, Iqbal S, Chiorean EG, Philip PA
S2303: phase II/III trial of paclitaxel + ramucirumab +/- nivolumab in gastric and esophageal adenocarcinoma (PARAMUNE)
Future Oncol. 2025;21(11):1325-1331 - PMID: 40155326 - PMCID: PMC12051544 - DOI: 10.1080/14796694.2025.2485020
Liu X, Liu Z, Kobayashi T, Lei PJ, Shi Y, Yuan D, Wang J, Li M, Matsui A, Mafra K, Huang P, Kuang M, Bod L, Duda DG
Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma.
bioRxiv. 2025;:ePub - PMID: 40093175 - PMCID: PMC11908210 - DOI: 10.1101/2025.03.04.641494
Roh K, Li H, Freeman RN, Zazzeron L, Lee A, Zhou C, Shen S, Xia P, Guerra JRB, Sheffield C, Padera TP, Zhou Y, Kim S, Aguirre A, Houstis N, Roh JD, Ichinose F, Malhotra R, Rosenzweig A, Rhee J
Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart.
Aging Cell. 2025;24(6):e70043 - PMID: 40083143 - PMCID: PMC12151892 - DOI: 10.1111/acel.70043
Westcott GP, Emont MP, Gulko A, Zhou Z, Kim C, Varma G, Tsai LL, O'Donnell E, Loureiro ZY, Liang W, Jacobs C, Tsai LT, Padera TP, Singhal D, Rosen ED
Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population.
bioRxiv. 2025;:ePub - PMID: 40027673 - PMCID: PMC11870541 - DOI: 10.1101/2025.02.18.638907
Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP
Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693
Harkos C, Hadjigeorgiou AG, Voutouri C, Kumar AS, Stylianopoulos T, Jain RK
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer.
Nat Rev Cancer. 2025;25(5):324-340 - PMID: 39972158 - DOI: 10.1038/s41568-025-00796-w
Yan J, Jiang Z, Zhang S, Yu Q, Lu Y, Miao R, Tang Z, Fan J, Wu L, Duda DG, Zhou J, Yang X
Spatial-temporal heterogeneities of liver cancer and the discovery of the invasive zone.
Clin Transl Med. 2025;15(2):e70224 - PMID: 39924620 - PMCID: PMC11807767 - DOI: 10.1002/ctm2.70224
Ren J, Amoozgar Z, Uccello TP, Lei PJ, Zhao Y, Ho WW, Huang P, Kardian A, Mack SC, Duda DG, Xu L, Jain RK
Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.
Proc Natl Acad Sci U S A. 2025;122(4):e2319474122 - PMID: 39841145 - PMCID: PMC11789170 - DOI: 10.1073/pnas.2319474122
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