Menzel L, Padera TP

Immune Privilege Within: Regulatory T Cells Tip the Balance in Favor of Lymph Node Metastasis.
Cancer Discov. 2025;15(9):1780-1782 - PMID: 40904098 - DOI: 10.1158/2159-8290.CD-25-1043

Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP

A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics.
Npj Imaging. 2025;3(1):2 - PMID: 40604254 - PMCID: PMC12091688 - DOI: 10.1038/s44303-024-00061-z

Hale AT, Kalailingam P, Kundishora AJ, Reeves BC, Brastianos PK, Shih HA, Jain RK, Ning M, Stapleton CJ, Patel AB, Smith ER, Chapman PH, Rabinov JD, Kleinstiver BP, Musolino PL, Kahle KT

An opportune time for targeted brain arteriovenous malformation therapy.
J Neurosurg. 2025;:1-4 - PMID: 40644723 - PMCID: PMC12477702 - DOI: 10.3171/2025.4.JNS25260

Mahfoud S, Padera TP

S1PR1, an endothelial-immune influencer.
J Exp Med. 2025;222(9):ePub - PMID: 40663043 - DOI: 10.1084/jem.20251056

Munn LL, Jain RK

Challenges and opportunities for the next generation of computational tumor models.
PLoS Biol. 2025;23(7):e3003269 - PMID: 40700394 - PMCID: PMC12286354 - DOI: 10.1371/journal.pbio.3003269

Lei PJ, Padera TP

Closing in on pacemaker cells.
Elife. 2025;14:ePub - PMID: 40693539 - PMCID: PMC12283070 - DOI: 10.7554/eLife.108102

Fanning JE, Tsai LL, Amore MA, Crescenzi R, De Paepe KN, Donohoe KJ, Maki JH, Padera TP, Pieper CC, Reynolds HM, Suami H, Singhal D

Bringing to Light the Invisible Lymphatic Anatomy of the Upper Extremity: Report From the 2024 Harvard Radcliffe Institute Accelerator Workshop.
Ann Surg. 2025;:ePub - PMID: 40767571 - DOI: 10.1097/SLA.0000000000006893

Duda DG, Javle M

A GOLP rush in biliary tract cancer: early promise in the quest for curative surgery.
Lancet Oncol. 2025;26(10):1265-1267 - PMID: 40889501 - DOI: 10.1016/S1470-2045(25)00427-9

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors.
bioRxiv. 2025;:ePub - PMID: 40894718 - PMCID: PMC12393523 - DOI: 10.1101/2025.08.20.671229

Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LH, Singh A, Fu J, Waterton SK, Cheng YC, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Immunity. 2025;58(7):1688-1705.e9 - PMID: 40592342 - PMCID: PMC12233199 - DOI: 10.1016/j.immuni.2025.06.005

Krishnan S, Lee S, Amoozgar Z, Subudhi S, Srinivasan Kumar A, Posada JM, Lindeman N, Lei P, Duquette M, Steinbuch S, Charabati M, Huang P, Andersson P, Datta M, Munn LL, Fukumura D, Jain RK

Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma.
Proc Natl Acad Sci U S A. 2025;122(38):e2414941122 - PMID: 40953263 - PMCID: PMC12478157 - DOI: 10.1073/pnas.2414941122

Duda DG, Abdel Wahab M, Takaori K

Thirty-Five years of globalizing surgical oncology knowledge: A look into the future - IASGO Cairo 2024.
Surg Oncol. 2025;63:102294 - PMID: 40967991 - DOI: 10.1016/j.suronc.2025.102294

O'Melia MJ, Menzel L, Lei PJ, Zhou H, Contreras-Alvarado N, Rajotte JJ, Liu L, Nikmaneshi MR, Baish JW, Ubellacker JM, Boland GM, Cohen S, Munn LL, Padera TP

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy.
bioRxiv. 2025;:ePub - PMID: 41000874 - PMCID: PMC12458325 - DOI: 10.1101/2025.09.17.676884

Dima SO, Sorop A, Kitahara S, Setia N, Chivu-Economescu M, Matei L, Herlea V, Pechianu NC, Inomata T, Matsui A, Khachatryan A, Aoki S, Lauwers GY, Popescu I, Duda DG

A tumor microenvironment-based classification of gastric cancer for more effective diagnosis and treatment.
Surg Oncol. 2025;63:102298 - PMID: 41033926 - DOI: 10.1016/j.suronc.2025.102298

O'Melia MJ, Sierra-Davidson K, Robert MA, Menzel L, Liu L, Lei PJ, Munn LL, Padera TP, Cohen S

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy.
bioRxiv. 2025;:ePub - PMID: 41040229 - PMCID: PMC12485707 - DOI: 10.1101/2025.09.22.677905

Tesfay MZ, Cios A, Ferdous KU, Shelton RS, Mustafa B, Simoes CC, Gokden M, Miousse IR, Krager KJ, Boerma M, Urbaniak A, Kunthur A, Obulareddy S, Eichhorn JM, Post SR, Chamcheu JC, Moaven O, Chabu CY, Duda DG, Conti M, Nardo B, Govindarajan R, Fernandez-Zapico ME, Roberts LR, Borad MJ, Cannon MJ, Basnakian AG, Nagalo BM

Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models.
Front Immunol. 2025;16:1679665 - PMID: 41142777 - PMCID: PMC12546120 - DOI: 10.3389/fimmu.2025.1679665

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK

Physiologically based pharmacokinetic model for CAR-T cell delivery and efficacy in solid tumors.
Proc Natl Acad Sci U S A. 2025;122(46):e2522634122 - PMID: 41218126 - DOI: 10.1073/pnas.2522634122

Gkika E, Firat E, Adebahr S, Graf E, Popp I, Eichhorst A, Radicioni G, Lo SS, Spohn SKB, Nestle U, Nicolay NH, Niedermann G, Grosu AL, Duda DG

A prospective study of immune responses in patients with lung metastases treated with stereotactic body radiotherapy with or without concurrent systemic treatment.
Radiother Oncol. 2025;207:110889 - PMID: 40209858 - DOI: 10.1016/j.radonc.2025.110889

Ren J, Amoozgar Z, Uccello TP, Lei PJ, Zhao Y, Ho WW, Huang P, Kardian A, Mack SC, Duda DG, Xu L, Jain RK

Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.
Proc Natl Acad Sci U S A. 2025;122(4):e2319474122 - PMID: 39841145 - PMCID: PMC11789170 - DOI: 10.1073/pnas.2319474122

Yan J, Jiang Z, Zhang S, Yu Q, Lu Y, Miao R, Tang Z, Fan J, Wu L, Duda DG, Zhou J, Yang X

Spatial-temporal heterogeneities of liver cancer and the discovery of the invasive zone.
Clin Transl Med. 2025;15(2):e70224 - PMID: 39924620 - PMCID: PMC11807767 - DOI: 10.1002/ctm2.70224

Harkos C, Hadjigeorgiou AG, Voutouri C, Kumar AS, Stylianopoulos T, Jain RK

Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer.
Nat Rev Cancer. 2025;25(5):324-340 - PMID: 39972158 - DOI: 10.1038/s41568-025-00796-w

Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP

Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693

Westcott GP, Emont MP, Gulko A, Zhou Z, Kim C, Varma G, Tsai LL, O'Donnell E, Loureiro ZY, Liang W, Jacobs C, Tsai LT, Padera TP, Singhal D, Rosen ED

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population.
bioRxiv. 2025;:ePub - PMID: 40027673 - PMCID: PMC11870541 - DOI: 10.1101/2025.02.18.638907

Roh K, Li H, Freeman RN, Zazzeron L, Lee A, Zhou C, Shen S, Xia P, Guerra JRB, Sheffield C, Padera TP, Zhou Y, Kim S, Aguirre A, Houstis N, Roh JD, Ichinose F, Malhotra R, Rosenzweig A, Rhee J

Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart.
Aging Cell. 2025;24(6):e70043 - PMID: 40083143 - PMCID: PMC12151892 - DOI: 10.1111/acel.70043

Liu X, Liu Z, Kobayashi T, Lei PJ, Shi Y, Yuan D, Wang J, Li M, Matsui A, Mafra K, Huang P, Kuang M, Bod L, Duda DG

Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma.
bioRxiv. 2025;:ePub - PMID: 40093175 - PMCID: PMC11908210 - DOI: 10.1101/2025.03.04.641494

Saeed A, Colby S, Oberstein PE, Duda DG, Park R, Agarwal R, Figueroa-Moseley C, Vaidya R, Unger JM, Guthrie KA, Rocha FG, Senthil M, Safyan RA, Wainberg ZA, Iqbal S, Chiorean EG, Philip PA

S2303: phase II/III trial of paclitaxel + ramucirumab +/- nivolumab in gastric and esophageal adenocarcinoma (PARAMUNE)
Future Oncol. 2025;21(11):1325-1331 - PMID: 40155326 - PMCID: PMC12051544 - DOI: 10.1080/14796694.2025.2485020

Nia HT, Munn LL, Jain RK

Probing the physical hallmarks of cancer.
Nat Methods. 2025;22(9):1800-1818 - PMID: 39815103 - DOI: 10.1038/s41592-024-02564-4

Duda D, Liu X, Liu Z, Kobayashi T, Lei PJ, Shi Y, Yuan D, Wang J, Li M, Matsui A, Mafra K, Huang P, Kuang M, Bod L

Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma.
Res Sq. 2025;:ePub - PMID: 40321752 - PMCID: PMC12047993 - DOI: 10.21203/rs.3.rs-6355345/v1

Talele NP, Kumra H, Gomes-Santos IL, Ho WW, Andersson P, Siwicki M, Huang P, Duda DG, Pittet MJ, Fukumura D, Jain RK

IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity.
J Immunother Cancer. 2025;13(5):ePub - PMID: 40413022 - PMCID: PMC12104899 - DOI: 10.1136/jitc-2024-011404

Munn LL

The cellular dance that splits vessels.
Proc Natl Acad Sci U S A. 2025;122(22):e2508260122 - PMID: 40424133 - PMCID: PMC12146740 - DOI: 10.1073/pnas.2508260122

Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR, Neurofibromatosis Clinical Trials Consortium

Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
J Neurooncol. 2025;173(3):751-757 - PMID: 40434540 - DOI: 10.1007/s11060-025-05020-1

Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Cancer Res. 2025;85(16):3139-3155 - PMID: 40439571 - PMCID: PMC12355177 - DOI: 10.1158/0008-5472.CAN-24-2232

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
Clin Cancer Res. 2025;31(16):3571-3580 - PMID: 40495423 - PMCID: PMC12351280 - DOI: 10.1158/1078-0432.CCR-24-4159

Voutouri C, Munn LL, Stylianopoulos T, Jain RK

Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions.
PLoS Comput Biol. 2025;21(6):e1013163 - PMID: 40504865 - PMCID: PMC12201673 - DOI: 10.1371/journal.pcbi.1013163
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