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Jain RK, Duda DG
Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 6th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2014;Chapter 4:(in press)
Chung E, Yeon C, Jain RK, Fukumura D
Uncovering tumor biology by intravital microscopy.
In: Comprehensive Biomedical Physics, Volume: IV 'Optical molecular imaging' (Editor: Kiessling Alves & Anders Brahme). Elsevier Press. 2014;:(in press)
Jain RK, Fukumura D, Duda DG
Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy.
In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Editor: LM McManus & RN Mitchell). Elsevier Press, Oxford. 2014;:(in press)
Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK
Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.
J Natl Cancer Inst. 2014;106(8):ePub - PMID: 25082335 - DOI: 10.1093/jnci/dju187
Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK
Vessel calibre-a potential MRI biomarker of tumour response in clinical trials.
Nat Rev Clin Oncol. 2014;11(10):566-584 - PMID: 25113840 - PMCID: PMC4445139 - DOI: 10.1038/nrclinonc.2014.126
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen B, Loeffler JS, Wen PY, Sorensen AG, Jain RK
Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients treated with cediranib with or without chemoradiation.
Neuro Oncol. 2014;16 Suppl 3:iii12 - PMID: 25165209 - PMCID: PMC4144509
Richter C, Seco J, Hong TS, Duda DG, Bortfeld T
Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism.
Med Hypotheses. 2014;83(4):477-81 - PMID: 25175713 - DOI: 10.1016/j.mehy.2014.08.004
Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
Nat Cell Biol. 2014;16(10):931-941 - PMID: 25218639 - PMCID: PMC4564017 - DOI: 10.1038/ncb3036
Jain RK, Netti PA
Letter to the editor regarding recent article by Wu et Al. [journal of theoretical biology, 355, 194-207 (2014)].
J Theor Biol. 2014;363:453 - PMID: 25219622 - DOI: 10.1016/j.jtbi.2014.08.052
Li W, Huang P, Chen DJ, Gerweck LE
Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control.
Radiother Oncol. 2014;113(1):146-9 - PMID: 25284063 - PMCID: PMC4280081 - DOI: 10.1016/j.radonc.2014.09.006
Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG
Magneto-fluorescent core-shell supernanoparticles.
Nat Commun. 2014;5:5093 - PMID: 25298155 - PMCID: PMC4264679 - DOI: 10.1038/ncomms6093
Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R
Correlative intravital imaging of cGMP signals and vasodilation in mice.
Front Physiol. 2014;5:394 - PMID: 25352809 - PMCID: PMC4196583 - DOI: 10.3389/fphys.2014.00394
Song JW, Bazou D, Munn LL
Microfluidic model of angiogenic sprouting.
Methods Mol Biol. 2014;1214:243-54 - PMID: 25468609 - DOI: 10.1007/978-1-4939-1462-3_15
Liao S, Jones D, Cheng G, Padera TP
Method for the quantitative measurement of collecting lymphatic vessel contraction in mice.
J Biol Methods. 2014;1(2):ePub - PMID: 25512945 - PMCID: PMC4264607 - DOI: 10.14440/jbm.2014.26
Zhang L, Li K, Sun R, Zhang Y, Ji J, Huang P, Yang H, Tian Y
Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.
Radiat Oncol. 2014;9(1):281 - PMID: 25498371 - PMCID: PMC4271325 - DOI: 10.1186/s13014-014-0281-8
Jain RK
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia.
Cancer Cell. 2014;26(5):605-622 - PMID: 25517747 - PMCID: PMC4269830 - DOI: 10.1016/j.ccell.2014.10.006
Babykutty S, Heishi T, Tsukada K, Huang Y, Kozin S, Conner D, Lin Q, Kucherlapati R, Jain RK, Fukumura D
Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.
Nitric Oxide. 2014;42C:115 - PMID: 25519573
Willett CG, Duda DG, Xu L, diTomaso E, Boucher Y, Czito B, Ancukiewicz M, Clark J, Carroll M, Lauwers G, Jain RK
Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
J Clin Oncol. 2008;26(15_suppl):4096 - PMID: 27949464
Jain RK, Janda KD, Saltzman WM
Drug discovery and delivery.
Mol Med Today. 1995;1(1):4 - PMID: 9415129 - DOI: 10.1016/1357-4310(95)80005-0
Berlin K, Jain RK, Richert C
Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.
Biotechnol Bioeng. 1998;61(2):107-18 - PMID: 10099504 - DOI: 10.1002/(sici)1097-0290(199821)61:2<107::aid-bit5>3.0.co;2-q
Chung HW, Chung HJ
Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.
Cancer Res. 2001;61(22):8347-50 - PMID: 11719469
Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG, Nocera DG
A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chem Sci. 2012;3(10):2980-2985 - PMID: 26413260 - PMCID: PMC4582792 - DOI: 10.1039/C2SC20212C
DiPette D, Ward-Hartley K, Jain RK
Effect of hyperglycemia on systemic hemodynamics and blood flow rate in normal and neoplastic tissues in rats
Cancer Res. 1986;46:6299-6304
Jones R, Capen D, Jacobson M, Munn L
PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension.
Cell Tissue Res. 2006;326(3):759-69 - PMID: 16794827 - DOI: 10.1007/s00441-006-0177-5
Friedrich EB, Tager AM, Liu E, Pettersson A, Owman C, Munn L, Luster AD, Gerszten RE
Mechanisms of leukotriene B4--triggered monocyte adhesion.
Arterioscler Thromb Vasc Biol. 2003;23(10):1761-7 - PMID: 12947016 - DOI: 10.1161/01.ATV.0000092941.77774.3C
Gerweck LE, Huang P, Lu HM, Paganetti H, Zhou Y
Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons.
Int J Radiat Oncol Biol Phys. 2014;89(1):161-6 - PMID: 24725699 - PMCID: PMC4298825 - DOI: 10.1016/j.ijrobp.2014.01.057
Garkavtsev IV, Tsvetkova TG, Yegolina NA, Gudkov AV
Variability of human rRNA genes: inheritance and nonrandom chromosomal distribution of structural variants of nontranscribed spacer sequences.
Hum Genet. 1988;81(1):31-7 - PMID: 3198124 - DOI: 10.1007/BF00283725
Stroh M, Duda DG, Takimoto CH, Yamazaki S, Vicini P
Translation of anticancer efficacy from nonclinical models to the clinic.
CPT Pharmacometrics Syst Pharmacol. 2014;3:e128 - PMID: 25098530 - PMCID: PMC4150926 - DOI: 10.1038/psp.2014.28
Fidler IJ, Yoneda J, Herrera C, Wood J, Xu L
Specific keynote: molecular determinants of angiogenesis in ovarian cancer.
Gynecol Oncol. 2003;88(1 Pt 2):S29-36; discussion S37-42 - PMID: 12586082 - DOI: 10.1006/gyno.2002.6680
Teague TK, Munn L, Zygourakis K, McIntyre BW
Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging.
Cytometry. 1993;14(7):772-82 - PMID: 8243206 - DOI: 10.1002/cyto.990140710
Saito Y, Sunamura M, Motoi F, Abe H, Egawa S, Duda DG, Hoshida T, Fukuyama S, Hamada H, Matsuno S
Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.
Cancer Gene Ther. 2006;13(3):242-52 - PMID: 16179928 - DOI: 10.1038/sj.cgt.7700902
Bucur O, Almasan A, Nikolajczyk BS, Nicolson GL, Lawler J, Velculescu VE, Draghici S, Leabu M, Avram D, Bucur I, Calautti E, Calin GA, Chauhan SC, Ciubotaru M, Constantinescu SN, Datta D, Duda DG, Friedman MT, Galardy PJ, Harris BT, Huarte M, Khalil AM, Marchetti D, Movileanu L, Nat R, Nucera C, Popa-Wagner A, Stancu AL, Zhu S, Liehn EA
Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry.
Discoveries (Craiova). 2013;1(1):e1 - PMID: 32309535 - PMCID: PMC6919543 - DOI: 10.15190/d.2013.1
Yuan J, Melder RJ, Jain RK, Munn LL
Lateral view flow system for studies of cell adhesion and deformation under flow conditions.
Biotechniques. 2001;30(2):388-94 - PMID: 11233608 - PMCID: PMC2752719 - DOI: 10.2144/01302rr02
Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL
Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
Proc Natl Acad Sci U S A. 2000;97(26):14608-13 - PMID: 11121063 - PMCID: PMC18966 - DOI: 10.1073/pnas.97.26.14608
Melder RJ, Yuan J, Munn LL, Jain RK
Erythrocytes enhance lymphocyte rolling and arrest in vivo.
Microvasc Res. 2000;59(2):316-22 - PMID: 10684738 - DOI: 10.1006/mvre.1999.2223
Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Microvasc Res. 2000;59(2):265-77 - PMID: 10684732 - DOI: 10.1006/mvre.1999.2225
Jain RK, Munn LL
Leaky vessels? Call Ang1!
Nat Med. 2000;6(2):131-2 - PMID: 10655092 - DOI: 10.1038/72212
Lichtenbeld HC, Ferarra N, Jain RK, Munn LL
Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.
Microvasc Res. 1999;57(3):357-62 - PMID: 10329263 - DOI: 10.1006/mvre.1998.2140
Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ
Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
Am J Pathol. 1997;150(6):2099-112 - PMID: 9176401 - PMCID: PMC1858325
Melder RJ, Koenig GC, Munn LL, Jain RK
Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.
Nat Immun. 1997;15(2-3):154-63 - PMID: 9162265
Munn LL, Melder RJ, Jain RK
Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.
Biophys J. 1996;71(1):466-78 - PMID: 8804629 - PMCID: PMC1233497 - DOI: 10.1016/S0006-3495(96)79248-2
Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK
During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
Nat Med. 1996;2(9):992-7 - PMID: 8782456 - DOI: 10.1038/nm0996-992
Patan S, Munn LL, Jain RK
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Microvasc Res. 1996;51(2):260-72 - PMID: 8778579 - DOI: 10.1006/mvre.1996.0025
Munn LL, Koenig GC, Jain RK, Melder RJ
Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.
Biotechniques. 1995;19(4):622-6, 628-31 - PMID: 8777057
Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RK
Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.
Biophys J. 1995;69(5):2131-8 - PMID: 8580357 - PMCID: PMC1236447 - DOI: 10.1016/S0006-3495(95)80087-1
Munn LL, Glacken MW, McIntyre BW, Zygourakis K
Analysis of lymphocyte aggregation using digital image analysis.
J Immunol Methods. 1993;166(1):11-25 - PMID: 8228280 - DOI: 10.1016/0022-1759(93)90324-z
Munn LL, Melder RJ, Jain RK
Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.
Biophys J. 1994;67(2):889-95 - PMID: 7948702 - PMCID: PMC1225432 - DOI: 10.1016/S0006-3495(94)80550-8
Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proc Natl Acad Sci U S A. 2012;109(38):15101-8 - PMID: 22932871 - PMCID: PMC3458380 - DOI: 10.1073/pnas.1213353109
Jain RK, Munn LL, Fukumura D
Corneal pocket assay in rabbits.
Cold Spring Harb Protoc. 2012;2012(9):1017-8 - PMID: 22949714 - DOI: 10.1101/pdb.prot070052
Duda DG, Willett CG
Going beyond systemic fluoropyrimidines with radiation therapy for rectal cancer: what should be the priority?
Oncology (Williston Park). 2012;26(8):741-3 - PMID: 22957407 - PMCID: PMC3682651
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