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Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, Yuan F, Jain RK
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Cancer Res. 1999;59(16):4129-35 - PMID: 10463618
Toyama T, Iwase H, Watson P, Muzik H, Saettler E, Magliocco A, DiFrancesco L, Forsyth P, Garkavtsev I, Kobayashi S, Riabowol K
Suppression of ING1 expression in sporadic breast cancer.
Oncogene. 1999;18(37):5187-93 - PMID: 10498868 - DOI: 10.1038/sj.onc.1202905
Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524
Garkavtsev I
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
Nat Genet. 1999;23(3):373 - PMID: 10545957 - DOI: 10.1038/15566
Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK
Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
Br J Cancer. 1999;81(5):756-9 - PMID: 10555742 - PMCID: PMC2374305 - DOI: 10.1038/sj.bjc.6690760
Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
J Biomech. 1999;32(12):1297-307 - PMID: 10569708 - DOI: 10.1016/s0021-9290(99)00125-6
McDonald DM, Munn L, Jain RK
Vasculogenic mimicry: how convincing, how novel, and how significant?
Am J Pathol. 2000;156(2):383-8 - PMID: 10666365 - PMCID: PMC1850027 - DOI: 10.1016/S0002-9440(10)64740-2
Hartford AC, Gohongi T, Fukumura D, Jain RK
Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Cancer Res. 2000;60(8):2128-31 - PMID: 10786673
Stohrer M, Boucher Y, Stangassinger M, Jain RK
Oncotic pressure in solid tumors is elevated.
Cancer Res. 2000;60(15):4251-5 - PMID: 10945638
Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK
Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
Shevkoplyas SS, Yoshida T, Munn LL, Bitensky MW
Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device.
Anal Chem. 2005;77(3):933-7 - PMID: 15679363 - PMCID: PMC3022340 - DOI: 10.1021/ac049037i
Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK
Tissue engineering: creation of long-lasting blood vessels.
Nature. 2004;428(6979):138-9 - PMID: 15014486 - DOI: 10.1038/428138a
Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Nature. 2004;428(6980):328-32 - PMID: 15029197 - DOI: 10.1038/nature02329
Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL
Differential gene expression in metastasizing cells shed from kidney tumors.
Cancer Res. 2004;64(7):2469-73 - PMID: 15059900 - DOI: 10.1158/0008-5472.can-03-0256
Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S
The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Pancreas. 2004;28(3):311-6 - PMID: 15084978 - DOI: 10.1097/00006676-200404000-00019
Brown EB, Boucher Y, Nasser S, Jain RK
Measurement of macromolecular diffusion coefficients in human tumors.
Microvasc Res. 2004;67(3):231-6 - PMID: 15121448 - DOI: 10.1016/j.mvr.2004.02.001
Duda DG, Fukumura D, Jain RK
Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Trends Mol Med. 2004;10(4):143-5 - PMID: 15162796 - DOI: 10.1016/j.molmed.2004.02.001
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074
Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK
Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752
Jain RK, Stroh M
Zooming in and out with quantum dots.
Nat Biotechnol. 2004;22(8):959-60 - PMID: 15286644 - DOI: 10.1038/nbt0804-959
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011
Sun C, Munn LL
Particulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis.
Biophys J. 2005;88(3):1635-45 - PMID: 15613630 - PMCID: PMC1305220 - DOI: 10.1529/biophysj.104.051151
Jain RK
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Science. 2005;307(5706):58-62 - PMID: 15637262 - DOI: 10.1126/science.1104819
Gohongi T, Todoroki T, Fukumura D, Jain RK
Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Oncol Rep. 2004;11(4):803-7 - PMID: 15010876
Garkavtsev I, Boucher Y
An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol.
Cancer Biol Ther. 2005;4(1):48-9 - PMID: 15711122 - DOI: 10.4161/cbt.4.1.1572
Duda DG, Jain RK
Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
J Clin Invest. 2005;115(3):596-8 - PMID: 15765145 - PMCID: PMC1052004 - DOI: 10.1172/JCI24511
Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Nat Med. 2005;11(6):678-82 - PMID: 15880117 - PMCID: PMC2686110 - DOI: 10.1038/nm1247
Jain RK
Antiangiogenic therapy for cancer: current and emerging concepts.
Oncology (Williston Park). 2005;19(4 Suppl 3):7-16 - PMID: 15934498
Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015
Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Xu L, Tong R, Cochran DM, Jain RK
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313
di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL
Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552
Jain RK, Au P, Tam J, Duda DG, Fukumura D
Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
Huang P, McKee TD, Jain RK, Fukumura D
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Forbes NS, Munn LL, Fukumura D, Jain RK
Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer Res. 2003;63(17):5188-93 - PMID: 14500342
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer Res. 2002;62(23):6831-6 - PMID: 12460895
Jain RK
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Semin Oncol. 2002;29(6 Suppl 16):3-9 - PMID: 12516032 - DOI: 10.1053/sonc.2002.37265
Mollica F, Jain RK, Netti PA
A model for temporal heterogeneities of tumor blood flow.
Microvasc Res. 2003;65(1):56-60 - PMID: 12535873 - DOI: 10.1016/s0026-2862(02)00012-2
Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Dolmans DE, Fukumura D, Jain RK
Photodynamic therapy for cancer.
Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879
Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Blood. 2003;102(7):2555-61 - PMID: 12775571 - DOI: 10.1182/blood-2003-02-0365
Jain RK
Molecular regulation of vessel maturation.
Nat Med. 2003;9(6):685-93 - PMID: 12778167 - DOI: 10.1038/nm0603-685
Jain RK, Duda DG
Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Cancer Cell. 2003;3(6):515-6 - PMID: 12842078 - DOI: 10.1016/s1535-6108(03)00138-7
Padera TP, Stoll BR, So PT, Jain RK
Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/15353500200200004
Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B
Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.
Microvasc Res. 2003;66(2):113-25 - PMID: 12935769 - DOI: 10.1016/s0026-2862(03)00039-6
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
Sunamura M, Duda DG, Ghattas MH, Lozonschi L, Motoi F, Yamauchi J, Matsuno S, Shibahara S, Abraham NG
Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.
Angiogenesis. 2003;6(1):15-24 - PMID: 14517400 - DOI: 10.1023/a:1025803600840
Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D
Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.
Clin Cancer Res. 2003;9(11):4221-6 - PMID: 14519649
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