Hengbo Zhou

Research Fellow

Hengbo Zhou

Research Fellow

Publications

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O'Melia MJ, Menzel L, Lei PJ, Zhou H, Contreras-Alvarado N, Rajotte JJ, Liu L, Nikmaneshi MR, Baish JW, Ubellacker JM, Boland GM, Cohen S, Munn LL, Padera TP

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy.
bioRxiv. 2025;:ePub - PMID: 41000874 - PMCID: PMC12458325 - DOI: 10.1101/2025.09.17.676884

Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP

Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Razavi MS, Zhou H, Menzel L, Huang L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Kurpios NA, Ubellacker JM, Padera TP

Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice.
Dev Cell. 2024;60(7):1118-1133.e5 - PMID: 39731913 - PMCID: PMC11981864 - DOI: 10.1016/j.devcel.2024.12.010

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Arroyo-Ataz G, Razavi MS, Zhou H, Menzel L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Ubellacker JM, Jones D, Padera TP

Lymphatic muscle cells are unique cells that undergo aging induced changes.
bioRxiv. 2023;:ePub - PMID: 38014141 - PMCID: PMC10680808 - DOI: 10.1101/2023.11.18.567621

Nikmaneshi MR, Baish JW, Zhou H, Padera TP, Munn LL

Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis.
Adv Sci (Weinh). 2023;10(36):e2304076 - PMID: 37949675 - PMCID: PMC10754116 - DOI: 10.1002/advs.202304076

Zhou H, Baish JW, O'Melia MJ, Darragh LB, Specht E, Czapla J, Lei PJ, Menzel L, Rajotte JJ, Nikmaneshi MR, Razavi MS, Heiden MGV, Ubellacker JM, Munn LL, Boland GM, Cohen S, Karam SD, Padera TP

Cancer immunotherapy responses persist after lymph node resection.
bioRxiv. 2023;:ePub - PMID: 37781599 - PMCID: PMC10541098 - DOI: 10.1101/2023.09.19.558262

Lei PJ, Pereira ER, Andersson P, Amoozgar Z, Van Wijnbergen JW, O'Melia MJ, Zhou H, Chatterjee S, Ho WW, Posada JM, Kumar AS, Morita S, Menzel L, Chung C, Ergin I, Jones D, Huang P, Beyaz S, Padera TP

Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes.
J Exp Med. 2023;220(9):ePub - PMID: 37341991 - PMCID: PMC10286805 - DOI: 10.1084/jem.20221847

Jones D, Wang Z, Chen I, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, Van Wijnbergen JW, Pereira E, Vakoc B, Huang P, Nia H, Padera T

Solid stress impairs lymphocyte infiltration into lymph node metastases.
FASEB J. 2022;36 Suppl 1:ePub - PMID: 35557097 - DOI: 10.1096/fasebj.2022.36.S1.R4616

Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP

Solid stress impairs lymphocyte infiltration into lymph-node metastases.
Nat Biomed Eng. 2021;5(12):1426-1436 - PMID: 34282290 - PMCID: PMC8678215 - DOI: 10.1038/s41551-021-00766-1

Zhou H, Lei PJ, Padera TP

Progression of Metastasis through Lymphatic System.
Cells. 2021;10(3):ePub - PMID: 33808959 - PMCID: PMC7999434 - DOI: 10.3390/cells10030627