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Imaged each step in the process of lymphatic metastasis and found that VEGF-C increases cancer cell arrival in the lymph node and thereby increases metastasis formation (Hoshida et al., 2006).
Using a chorioallantoic membrane model and in vivo microscopy, characterized the early events in metastasis and examined the induction of metastasis-related genes (Shioda et al., 1997). |
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Metastasis: Hematogeneous Several interdependent mechanisms influence the metastatic cascade, and despite the impressive rate of publication in this area (> 10,000 hits on Medline from 2000 to 2006), we still know little about the key steps in the process. An outstanding question in the field of metastasis is whether cancer cells need to actively adhere to and migrate out of blood vessels at the secondary site in order to colonize. On the one hand, we know that cancer cells express endothelial adhesion receptors, similar to leukocytes, that allow them to roll on and adhere to endothelium. But other studies have found clumps of cancer cells surviving and growing within the lumen of blood vessels at the secondary site. |
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Demonstration that telopeptide-free collagen I enhances RhoA activity and the invasion of a metastatic breast tumor cell line (Demou et al., 2005). |
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Solid stress is transmitted through the structural elements of the interstitium and the cells. It is independent of hydrostatic pressure, which is transmitted through intra- and extracellular fluids. Cell proliferation in a confined space creates solid stress, which exerts forces on these structural elements, affecting the cells themselves as well as blood vessels. Recent reports show that gene expression in developing embryos is affected by applied mechanical stress. Mechanical stress also leads to phenotypic changes in adult cells, including cancer cells. In this project, we investigate the factors that contribute to solid stress in tumors, determine the effects of solid stress on tumor physiology, gene expression in cancer and stromal cells, and evaluate whether increased solid stress promotes metastasis. |
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