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(Tentative schedule)
25th Annual Offering of
Critical Issues in Tumor Microenvironment, Angiogenesis and Metastasis:
from Bench to Bedside and Back
September 27 - 30 , 2010
25th Anniversary Celebration
Sunday September 26, 2010

 

Purpose

Most cancer research to date has focused on understanding the biology of tumor cells in vitro with limited attention paid to the in vivo microcirculatory environment in which these cells reside. Since nothing can reach tumor cells from blood without passing through the vascular and interstitial compartments, it seems reasonable to find out more about the structure and function of these two compartments.

The objective of this course is to discuss our current understanding of the tumor microcirculation and angiogenesis, and their relationship with metastasis. Emphasis will be placed on their pathophysiological significance and clinical relevance.

 

 

 


 


 

Course Director

Rakesh K. Jain, Ph.D., Andrew Werk Cook Professor of Tumor Biology, Harvard Medical School; Director, E.L. Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital; and Professor, Harvard-MIT Division of Health Sciences and Technology, Boston, MA, USA

 

Faculty

 

  • Lisa Coussens, Ph.D. Professor, Pathology; Co-Director, Mouse Pathology Core; University of California, San Francisco; Departnment of Pathology and Laboratory Medicine; Pathology and Cancer Research Institute; San Francisco, CA, USA
  • Harold F. Dvorak, M.D., Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School; Founding Director, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA, USA
  • Isaiah J.Fidler D.V.M., Ph.D., R.E. “Bob” Smith Distinguished Chair in Cell Biology; Chairman, Department of Cancer Biology; Director, Cancer Metastasis Research Center; Professor of Cancer Biology and Urology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • Rakesh K. Jain, Ph.D., Andrew Werk Cook Professor of Tumor Biology, Harvard Medical School; Director, E.L. Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital; and Professor, Harvard-MIT Division of Health Sciences and Technology, Boston, MA, USA
  • Robert S. Kerbel, Ph.D., Canada Research Chair in Molecular Medicine; Senior Scientist, Molecular and Cell Biology Research, Sunnybrook and Women’s College Health Sciences Centre/Toronto-Sunnybrook Regional Cancer Center; Professor, Departments of Medical Biophysics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
  • Raju Kucherlapati, Ph.D., Paul C. Cabot Professor of Genetics and Professor of Medicine, Harvard Medical School, Department of Genetics, Boston, MA, USA
  • Marsha Moses, Ph.D., Professor of Surgery, Harvard Medical School; Director, Vascular Biology Program, Children's Hospital, Boston, MA, USA
  • George W. Sledge, M.D., Ballve-Lantero Professor of Medicine and Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • A. Gregory Sorensen, M.D., Associate Professor of Radiology, Harvard Medical School; Associate Professor of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology; Director, Center for Biomarkers in Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Daniel D. Von Hoff, M.D., F.A.C.P., Physician-in-Chief, Senior Investigator, Translational Genomics Research Institute, (TGen); and Clinical Professor of Medicine, University of Arizona, Arizona Cancer Center, Arizona Health Sciences Center, Phoenix, AZ, USA.
  • Robert A. Weinberg, Ph.D., Ludwig Professor for Cancer Research and American Cancer Society Professor of Biology, Massachusetts Institute of Technology; Founding member of the Whitehead Institute, Cambridge, MA, USA
Lecture Schedule - Tentative Schedule

Monday September 27, 2010

7:30 A.M. Registration

8:00 A.M. Continental Breakfast

8:30 A.M. Opening Remarks Jain

9:00 A.M. Tumor Microenvironment I: Angiogenesis and Vascular Transport Jain

10:00 A.M. Coffee Break

10:30 A.M. Tumor Microenvironment II: Interstitial and Lymphatic Transport Jain

Noon - Lunch provided on site

1:30 P.M. Normalization of Tumor Vasculature and Microenvironment by Antiangiogenic Therapy: Bench to Bedside and Back Jain

3:00 P.M. Coffee Break

3:30 P.M. Taking Low-Dose Metronomic Chemotherapy from a Preclinical Concept to a Promising Clinical Treatment for Metastatic Disease Kerbel

5:00 P.M. Adjourn

 

Tuesday September 28, 2010

 

8:00 A.M. Continental Breakfast

8:30 A.M. The Biology of Cancer Metastasis Fidler

10:00 A.M. Coffee Break

10:30 A.M. Therapy of Cancer Metastasis: Attacking the Stroma Fidler

Noon Lunch (on your own)

1:30 P.M. From a Model of Vessel Branching to Developing Anti-Angiogenic Agents Carmeliet

3:00 P.M. Coffee Break

3:30 P.M. Hypoxia, Oxygen Sensing and Vessel Morphogenesis: Implications for Metastasis Carmeliet

5:00 P.M. Adjourn

 

Wednesday September 29, 2010

 

8:00 AM Continental Breakfast

8:30 A.M. Genetics in Cancer Therapy Kucherlapati
10:00 A.M. Coffee Break

10:30 A.M. Tumor Stroma Generation: Role of VPF/VEGF Dvorak

Noon Lunch (on your own)

1:30 P.M. Molecular Mechanisms of Tumor Progression and Metastasis Weinberg

3:00 P.M. Coffee Break
3:30 P.M. Mining the Human Proteome: Biomarker Discovery for Human Cancer and Its Metastases Moses
5:00 P.M. Adjourn

 

Thursday September 30, 2010

 

8:00 A.M. Continental Breakfast

8:30 A.M. Endothelium + Stroma: Double Trouble Von Hoff

10:00 A.M. Coffee Break

10:30 A.M. Lessons from Clinical Trials of Targeted Therapies for Cancer Sledge

Noon - Lunch provided on site

1:30 P.M. Imaging Angiogenesis and Vascular Function in Cancer Patients Sorensen

3:00 P.M. Summary and closing remarks Jain

 

Who Should Attend This Course?
Cancer researchers and clinicians in the pharmaceutical industry, biotechnology industry, federal research laboratories, and universities whose research lies in the following areas:
Angiogenesis
Bioengineering
Biomarkers
Biophysics
Biorheology
Chemotherapy
Clinical Studies
Combination Therapies
Diagnostic Radiology
Drug Delivery
Experimental Therapeutics
Gene Therapy
Hematology
Immunotherapy
Inflammation
Lymphatic Vessel Biology
Metastasis
Microcirculation
Molecular Imaging
Monoclonal Antibodies
NMR
Nanomedicine
Nanotechnolgy
Neurology
Nuclear Medicine
Oncology
Pathology
Pathophysiology
Personalized Medicine
PET
Pharmacokinetics
Pharmacology
Photodynamic Therapy
Radiation Biology
Radioimmunodetection
Radioimmunotherapy
Radiotherapy
Surgery
Translational Studies
Tumor Biology
Tumor Microenvironment
Vasculogenesis

 

Educational Support (2009)

Platinum Tier

Genentech BioOncology

Millennium Pharmaceuticals, Inc.

Golden Tier

Cephalon

OSI Oncology

ThromboGenics

Supporters

AstraZeneca Pharmaceuticals

Dyax Corporation

Varian Medical Systems Foundation

 


Accreditation

Harvard Medical School' Department of Continuing Education (HMS-CME) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Registration Information

Tuition Fees -

$995 (USD) 22 Hours ACCME for Physicians & Health Professionals.

$895* (USD) * for Residents and Fellows in Training * A letter of verification from your Department Chair must accompany your registration form for a reduced fee option.

$700 (USD) - for Past Participants of Tumor Microcirculation Course.

 

Registration provides 4 days of Faculty Lectures with a 1,000 page + Course Notebook & CD.
Upon receipt of registration, a confirmation letter from HMS-CME will be mailed to your address given on the form.

 

Online Registration Information

Registrations paid by credit/debit card may be submitted online at the HMS-DCE website. Please click here to register on-line.

HMS-CME registration form for this course may be mailed directly, with your payment. Please click here to download the form.

Please note: All foreign payments must be made by a draft on a United States bank or by Visa of Mastercard.

Telephone registrations are not accepted.

Inquiries may be directed to the Harvard Medical School Department of Continuing Medical Education:

e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it or Mon-Friday, 10am - 4:00pm Eastern Standard Time -617-384-8600


Refund Policy

A handling fee of $60 is deducted for cancellation. Refund requests must be received by mail or fax one week prior to course. No refund will be made thereafter.

 


Course Location

All of the 2009 Tumor Course sessions will be held at the Royal Sonesta Hotel, located at 5 Cambridge Parkway, Cambridge, MA 02142; phone: 617-806-4200 Fax: 617-806-4232

 


Accommodations

Hotel rooms in Boston and Cambridge are limited. You are urged to make your reservations early. A limited number of rooms have been reserved at the Royal Sonesta Hotel until August 31, 2009. Please specify that you are enrolled in this course to receive the reduced room rate of $259 (USD) Single/Double with 12.45% tax.

 


Travel

For information about reduced travel, call the Harvard MED-CME at (617) 384-8600, Monday-Friday, 10 a.m. to 4 p.m. (Eastern Time).

 

Future Course Dates:

 

September 2011

 



 

 

 

 
 
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