Position: POSTDOCTORAL RESEARCH FELLOW – TUMOR MICROENVIRONMENT, VASCULR BIOLOGY, MATRIX BIOLOGY, IMMUNOLOGY, MOLECULAR/CELLULAR BIOLOGY, INTRAVITAL MICROSCOPY and BIOMEDICAL ENGINEERING

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-19

Description: The JAIN LAB in the STEELE LABORATORIES OF TUMOR BIOLOGY at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. Multiple positions are available in tumor microenvironment, vascular biology, matrix biology, immunology, molecular/cellular biology, intravital microscopy and biomedical engineering. Ideal candidates should have a strong academic background, peer-reviewed publications, strong English language proficiency and writing skills. Candidates with a strong background in single-cell-sequencing, bioinformatics, Python, and R statistical computing are also encouraged to apply. The Steele Labs have a diverse faculty and offer a lively and supportive environment in which to perform cutting-edge interdisciplinary research. Our research goals are (i) to understand how the abnormal tumor microenvironment confers resistance to various cancer treatments (e.g., molecular therapeutics, nanotherapeutics, radiation and immunotherapy), (ii) to develop and test new strategies to overcome this resistance, and (iii) to translate these strategies from bench to bedside through multi-disciplinary clinical trials. This tight integration between bench and bedside and application of engineering/physical science principles to oncology is a hallmark of our research.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative molecular, genetic, cellular, and computational approaches in their work. Research fellows are encouraged to apply for post-doctoral fellowships and to write their own transition grants to launch their independent research careers following their training period. Salary will be commensurate with qualifications and experience with additional funding for conferences and training seminars.

Requirements: A PhD or MD/PhD is required. To apply, please send your CV, a career statement, a summary of your most significant research accomplishments (300 words) and the contact information of three references to: Steele Labs Recruiting jobs@steele.mgh.harvard.edu.


Position: Postdoctoral fellowship on reprogramming pancreatic ductal adenocarcinoma microenvironment to improve immunotherapy

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-15

Description: The Steele Laboratories at Massachusetts General Hospital and Harvard Medical School are currently seeking postdoctoral fellow applicants to define the molecular and cellular mechanism underlying the reprogramming of tumor microenvironment to improve immunotherapy. Applicants with a strong training background, experience and publication track record in the following areas are highly encouraged to apply – molecular and cell biology, flow cytometry and FACS, omics (genomics, transcriptomics proteomics and metabolomics), immunohistochemistry and imaging, and/or murine models of cancer.

Responsibilities: Individuals must have a Ph.D. M.D., and/or equivalent degree, appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. To begin the application process, please e-mail a current CV and statement of purpose to jobs@steele.mgh.harvard.edu.

Requirements: The Steele Laboratories at Massachusetts General Hospital and Harvard Medical School are currently seeking postdoctoral fellow applicants to define the molecular and cellular mechanism underlying the reprogramming of tumor microenvironment to improve immunotherapy. Applicants with a strong training background, experience and publication track record in the following areas are highly encouraged to apply – molecular and cell biology, flow cytometry and FACS, omics (genomics, transcriptomics proteomics and metabolomics), immunohistochemistry and imaging, and/or murine models of cancer.


Position: Postdoctoral Fellow

Research Area: Breast cancer brain metastasis

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-13

Description: The Steele Laboratory is currently seeking a postdoctoral applicant with expertise in breast cancer cell signaling and microenvironment. The position requires a highly motivated and independent researcher to carry out a project aimed at exploring brain-dependent signaling mechanisms to overcome resistance to targeted therapy andto restore anti-tumor immunity. Please see our recent papers for more information about our focus and experimental setup: 1) Askoxylakis et. al., Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment, JNCI 2015 2) Kodack et. al., Emerging strategies for treating brain metastases from breast cancer, Cancer Cell 2015. Experience in the following technical areas is preferred: molecular and cell biology, biochemistry, flow cytometry and FACS, immunohistochemistry and imaging, and murine models of cancer.

Requirements: Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. Applicants with a strong training background and publication track record in brain tumors are highly encouraged to apply. Experience in the following technical areas is preferred: immunohistochemistry, imaging and murine models of cancer. To begin the application process, please e-mail a current CV and statement of purpose to jobs@steele.mgh.harvard.edu


Position: Postdoctoral Fellowship in Tuberculosis Granuloma Microenvironment

Research Area: Tuberculosis Research

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-13

Description: The Steele Laboratories are currently seeking postdoctoral applicants with expertise in tuberculosis research with extensive experience in immunohistochemistry and tuberculosis pathology. Experience with image analysis is highly preferred. The postdoctoral fellow will participate in an exciting multidisciplinary project aimed at studying the vasculature and matrix of tuberculosis granulomas. The project is funded by the Bill and Melinda Gates Foundation to Prof. Rakesh Jain, with leading tuberculosis collaborators from the NIH and Rutgers University.

Requirements: Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. US citizens and permanent US residents are encouraged to apply. To begin the application process, please e-mail a current CV and statement of purpose tojobs@steele.mgh.harvard.edu


Position: Postdoctoral Fellowship in Glioblastoma Microenvironment and Anti-Tumor Immunity

Research Area: Glioblastoma

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-13

Description: The Steele Laboratories are currently seeking postdoctoral applicants with expertise in glioblastoma immunity and microenvironment to explore alternatives to current anti-VEGF treatment and modulation of the associated tumor immune component. Applicants with a strong training background and publication track record in immunology are highly encouraged to apply. Experience in the following technical areas is preferred: molecular and cell biology, flow cytometry and FACS, immunohistochemistry and imaging, and murine models of cancer.

Requirements: Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. US citizens and permanent US residents are encouraged to apply. To begin the application process, please e-mail a current CV and statement of purpose to jobs@steele.mgh.harvard.edu


Position: Postdoctoral Fellow in Brain Tumors and Intravital Microscopy

Research Area: Glioblastoma

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-13

Description: The Steele Laboratory is currently seeking a postdoctoral applicant with training and research experience in tumor biology to carry out exciting multidisciplinary projects aimed at understanding tumor microenvironment in brain tumors. Expertise in animal studies and intravital imaging are necessary for the study.

Requirements: Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. Applicants with a strong training background and publication track record in brain tumors are highly encouraged to apply. Experience in the following technical areas is preferred: immunohistochemistry, imaging and murine models of cancer. To begin the application process, please e-mail a current CV and statement of purpose to jobs@steele.mgh.harvard.edu


Position: Postdoctoral Fellow in pediatric brain tumors

Research Area: Pediatric Brain Cancers (medulloblastoma, ependymoma, glioma)

Full/Part Time: Full Time

Investigator: Jain, Rakesh

Date Posted: 2022-01-13

Description: The Steele Laboratory is currently seeking a postdoctoral applicant with training and research experience in tumor biology to carry out exciting multidisciplinary projects aimed at understanding the tumor micro-environment in pediatric brain tumors. Expertise in molecular biology, immunology, animal study and intra-vital imaging are necessary for the study.

Responsibilities: Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. Experience in the following technical areas is preferred: molecular and cell biology, flow cytometry and FACS, immunohistochemistry, imaging and murine models of cancer. To begin the application process, please e-mail a current CV and statement of purpose to jobs@steele.mgh.harvard.edu


Position: Postdoctoral Fellow

Research Area: Mechanics of brain tumor growth and immunotherapy

Full/Part Time: Full Time

Investigator: Munn, Lance

Date Posted: 2021-08-03

Description: Postdoctoral Research position in the Edwin L. Steele Laboratories at Massachusetts General Hospital. The NIH funded project focuses on brain tumor mechanics and immunotherapy. Applicants must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. The successful candidate will have training in engineering, immunology and/or tumor biology. Experience with small animal surgery and mechanobiology is a plus. Applicants should send a C.V., career statement and 3 letters of recommendation to: munn@steele.mgh.harvard.edu


Position: Postdoctoral Fellow

Research Area: Tissue engineering and tumor biology

Full/Part Time: Full Time

Investigator: Munn, Lance

Date Posted: 2021-08-03

Description: Postdoctoral Research position in the Edwin L. Steele Laboratories at Massachusetts General Hospital. The NIH funded project focuses on tumor tissue engineering and drug testing. Applicants must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. The successful candidate will have training in tissue engineering, microfabrication and vascular biology. Experience with tumor biology is a plus. Applicants should send a C.V., career statement and 3 letters of recommendation to: munn@steele.mgh.harvard.edu


Position: Postdoctoral Fellow

Research Area: Development of diagnostic devices for COVID-19 -related coagulopathies

Full/Part Time: Full Time

Investigator: Munn, Lance

Date Posted: 2021-08-03

Description: Postdoctoral Research position in the Edwin L. Steele Laboratories at Massachusetts General Hospital. The NIH funded project focuses on development of diagnostic devices for blood coagulopathies. Applicants must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. The successful candidate will have training in blood rheology, thrombosis and microfabrication. Applicants should send a C.V., career statement and 3 letters of recommendation to: munn@steele.mgh.harvard.edu


Position: Research technologist

Research Area: Clinical Correlative Studies Core

Full/Part Time: Full Time

Investigator: Xu, Lei

Date Posted: 2013-03-05

Description: We are looking for a Research Technologist to join our Clinical Correlative Studies Core at the Edwin L. Steele Laboratory. The Technologist will have the primary responsibility of measuring protein concentration in blood and tissue samples from patients enrolled in clinical trials at the Massachusetts General Hospital.

Requirements: Individuals must have a BSc degree, appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic team environment. Previous experience in enzyme-linked immuno-sorbent assay (ELISA), immunohistochemistry, flow cytometry, molecular biology and animal experimentation is preferred. Interested candidates should send a cover letter and resume to: </br> Lei Xu, M.D, Ph.D.</br> Edwin L. Steele Laboratory</br> Massachusetts General Hospital</br> 100 Blossom Street, Cox-7</br> Boston, MA 02114</br> E-mail: <a href="mailto:lei@steele.mgh.harvard.edu">lei@steele.mgh.harvard.edu</a>


Position: Postdoctoral Fellows

Research Area: Nitric Oxide angiogenesis, and/or intravital Microscopy

Full/Part Time: Full Time

Investigator: Fukumura, Dai

Date Posted: 2013-03-05

Description: The Steele Laboratory is currently seeking postdoctoral applicants with expertise in nitric oxide, angiogenesis, vessel maturation, molecular biology, and/or intravital microscopy. The project requires a motivated, independent researcher to carry out a project aimed at understanding role of nitric oxide in tumor angiogenesis, microcirculation and radiation therapy.

Requirements: Applicants should send a CV, career statement and three letters of reference to: </br> Dai Fukumura, MD, PhD</br> Associate Professor</br> Massachusetts General Hospital & Harvard Medical School</br> 100 Blossom Street, Cox Building 736, Boston, MA 02114</br> <a href="mailto;dai@steele.mgh.harvard.edu">dai@steele.mgh.harvard.edu</a>